LAMP2 Antibody (Ascites) (OAAB06711)

Catalog No: OAAB06711

Size:0.1ml

LAMP2 Antibody (N-term) (Cat. #OAAB06711) western blot analysis in mouse NIH-3T3 cell line lysates (15ug/lane).This demonstrates the LAMP2 antibody detected the LAMP2 protein (arrow).

LAMP2 Monoclonal (ascites) (Cat. #OAAB06711) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LAMP2 Monoclonal (ascites) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. Crude ascites with 0.09% (W/V) sodium azide.
• Clonality: Monoclonal
• Clone: 157CT16.6.6
• Isotype: IgG1,k
• Host: Mouse
• Application: WB, IHC-P
  Function: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
  Cellular Location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Lysosome membrane; Single-pass type I membrane protein. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
  Tissue Location: Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This LAMP2 monoclonal antibody is generated from mouse immunized with LAMP2 recombinant protein.
• Application Info: IHC-P: 1:50~100
  WB: 1:16000
• Intended Use: LAMP2 Antibody (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
• Publications:

  The role of lysosomes and autophagosomes in frontotemporal lobar degeneration. Neuropathol Appl Neurobiol. 45, 244-261 (2019). WB, IHC-P, Human, Mouse 29790198

Target Info

• Gene Symbol: LAMP2
• Alias Symbols: DND, LAMPB, CD107b, LAMP-2, LGP-96, LGP110
• NCBI Gene Id: 3920
• Protein Name: Lysosome-associated membrane glycoprotein 2
• Description of Target: Mouse Monoclonal Antibody (Mab) to LAMP2
• Uniprot ID: P13473
• Protein Accession #: NP_054701.1
• Molecular Weight: 44961 Da